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1

How to Build a DNA Unwinding Machine

Mark D. Szczelkun, Mark S. Dillingham

Journal:

Year:

2012

Language:

english

File:

PDF, 259 KB

english, 2012

2

The H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1 helicase-like motor

Toliusis, Paulius, Tamulaitiene, Giedre, Grigaitis, Rokas, Tuminauskaite, Donata, Silanskas, Arunas, Manakova, Elena, Venclovas, Česlovas, Szczelkun, Mark D, Siksnys, Virginijus, Zaremba, Mindaugas

Journal:

Nucleic Acids Research

Year:

2018

Language:

english

File:

PDF, 6.67 MB

english, 2018

3

Mitochondrial import, health and mtDNA copy number variability using type II and type V CRISPR effectors

AntÃ³n, ZuriÃ±e, Mullally, Grace, Ford, Holly, van der Kamp, Marc W., Szczelkun, Mark D., Lane, Jon D.

Journal:

Journal of Cell Science

Year:

2020

File:

PDF, 19.81 MB

2020

4

Comparison Between Shear Force and Tapping Mode AFM - High Resolution Imaging of DNA

Massimo Antognozzi, Mark D. Szczelkun, Andrew N. Round, Mervyn J. Miles

Journal:

Single Molecules

Year:

2002

Language:

english

File:

PDF, 268 KB

english, 2002

5

How to get from A to B: strategies for analysing protein motion on DNA

Stephen E. Halford, Mark D. Szczelkun

Journal:

European Biophysics Journal

Year:

2002

Language:

english

File:

PDF, 241 KB

english, 2002

6

Book reviews

Neil Hopper, Claire-Louise Palmer, Mark D. Szczelkun

Journal:

Molecular Biotechnology

Year:

2002

Language:

english

File:

PDF, 72 KB

english, 2002

7

Motor step size and ATP coupling efficiency of the dsDNA translocase EcoR124I

Seidel, Ralf, Bloom, Joost GP, Dekker, Cees, Szczelkun, Mark D

Journal:

The EMBO Journal

Year:

2008

Language:

english

File:

PDF, 537 KB

english, 2008

8

Dynamics of initiation, termination and reinitiation of DNA translocation by the motor protein EcoR124I

Seidel, Ralf, Bloom, Joost G P, van Noort, John, Dutta, Christina F, Dekker, Nynke H, Firman, Keith, Szczelkun, Mark D, Dekker, Cees

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 998 KB

english, 2005

9

When a helicase is not a helicase: dsDNA tracking by the motor protein EcoR124I

Stanley, Louise K, Seidel, Ralf, van der Scheer, Carsten, Dekker, Nynke H, Szczelkun, Mark D, Dekker, Cees

Journal:

The EMBO Journal

Year:

2006

Language:

english

File:

PDF, 439 KB

english, 2006

10

A general assay for restriction endonucleases and other DNA-modifying enzymes with plasmid substrates

I. Barry Vipond, Geoffrey S. Baldwin, Mark Oram, Symon G. Erskine, Lois M. Wentzell, Mark D. Szczelkun, Timothy J. Nobbs, Stephen E. Halford

Journal:

Molecular Biotechnology

Year:

1995

Language:

english

File:

PDF, 1014 KB

english, 1995

11

Random walk models for DNA synapsis by resolvase

Richard B Sessions, Mark Oram, Mark D Szczelkun, Stephen E Halford

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 910 KB

english, 1997

12

Selection of non-specific DNA cleavage sites by the type IC restriction endonuclease EcoR124I

Mark D Szczelkun, Pavel Janscak, Keith Firman, Stephen E Halford

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 383 KB

english, 1997

13

DNA excision by the SfiI restriction endonuclease

Timothy J Nobbs, Mark D Szczelkun, Lois M Wentzell, Stephen E Halford

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 667 KB

english, 1998

14

Subunit assembly and mode of DNA cleavage of the type III restriction endonucleases EcoP1I and EcoP15I

Pavel Janscak, Ursula Sandmeier, Mark D Szczelkun, Thomas A Bickle

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 500 KB

english, 2001

15

Analysis of DNA looping interactions by type II restriction enzymes that require two copies of their recognition sites

Susan E. Milsom, Stephen E. Halford, Michelle L. Embleton, Mark D. Szczelkun

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 335 KB

english, 2001

16

S-Adenosyl Methionine Prevents Promiscuous DNA Cleavage by the EcoP1I type III Restriction Enzyme

Luke J. Peakman, Massimo Antognozzi, Thomas A. Bickle, Pavel Janscak, Mark D. Szczelkun

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 1.43 MB

english, 2003

17

Continuous Assays for DNA Translocation Using Fluorescent Triplex Dissociation: Application to Type I Restriction Endonucleases

Sarah E. McClelland, David T.F. Dryden, Mark D. Szczelkun

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 867 KB

english, 2005

18

The Interrelationship of Helicase and Nuclease Domains during DNA Translocation by the Molecular Motor EcoR124I

Eva Šišáková, Marie Weiserová, Cees Dekker, Ralf Seidel, Mark D. Szczelkun

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.12 MB

english, 2008

19

A chlorite mineral surface actively drives the deposition of DNA molecules in stretched conformations

Antognozzi, Massimo, Wotherspoon, Alex, Hayes, Jonathan M, Miles, Mervyn J, Szczelkun, Mark D, Valdrè, Giovanni

Journal:

Year:

2006

Language:

english

File:

PDF, 793 KB

english, 2006

20

Single-Molecule Studies Of ATP-Dependent Restriction Enzymes

Schwarz, Friedrich W., Ramanathan, Subramanian P., van Aelst, Kara, Szczelkun, Mark D., Seidel, Ralf

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 53 KB

english, 2009

21

Type III Restriction Enzymes Use 1D Diffusion to Communicate the Relative Orientation of their Distant Target Sites

Schwarz, Friedrich W., Tóth, Julia, van Aelst, Kara, Cui, Guanshen, Szczelkun, Mark D., Seidel, Ralf

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 36 KB

english, 2011

22

Sequence-Specific Binding of DNA by the EcoRV Restriction and Modification Enzymes with Nucleic Acid and Cofactor Analogs

Szczelkun, Mark D., Connolly, Bernard A.

Journal:

Year:

1995

Language:

english

File:

PDF, 3.03 MB

english, 1995

23

Enzyme-Mediated DNA Looping

Halford, Stephen E., Welsh, Abigail J., Szczelkun, Mark D.

Journal:

Annual Review of Biophysics and Biomolecular Structure

Year:

2004

Language:

english

File:

PDF, 381 KB

english, 2004

24

Kinetic Models of Translocation, Head-On Collision, and DNA Cleavage by Type I Restriction Endonucleases †

Szczelkun, Mark D.

Journal:

Year:

2002

Language:

english

File:

PDF, 170 KB

english, 2002

25

Probing the Protein-DNA Interface of the EcoRV Modification Methyltransferase Bound to Its Recognition Sequence, GATATC

Szczelkun, Mark D., Jones, Helen, Connolly, Bernard A.

Journal:

Year:

1995

Language:

english

File:

PDF, 3.21 MB

english, 1995

26

Type III restriction enzymes cleave DNA by long-range interaction between sites in both head-to-head and tail-to-tail inverted repeat

Kara van Aelst, Júlia Tóth, Subramanian P. Ramanathan, Friedrich W. Schwarz, Ralf Seidel, Mark D. Szczelkun and Martin Gellert

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.72 MB

english, 2010

27

Translocation, switching and gating: potential roles for ATP in long-range communication on DNA by Type III restriction endonucleases

Szczelkun, Mark D.

Journal:

Biochemical Society Transactions

Year:

2011

Language:

english

File:

PDF, 478 KB

english, 2011

28

Maintaining a sense of direction during long-range communication on DNA

Szczelkun, Mark D., Friedhoff, Peter, Seidel, Ralf

Journal:

Biochemical Society Transactions

Year:

2010

Language:

english

File:

PDF, 406 KB

english, 2010

29

Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes

Chand, Mahesh K, Nirwan, Neha, Diffin, Fiona M, van Aelst, Kara, Kulkarni, Manasi, Pernstich, Christian, Szczelkun, Mark D, Saikrishnan, Kayarat

Journal:

Nature Chemical Biology

Year:

2015

Language:

english

File:

PDF, 3.14 MB

english, 2015

30

Switching roles for a helicase

Seidel, Ralf, Szczelkun, Mark D

Journal:

Year:

2013

Language:

english

File:

PDF, 563 KB

english, 2013

31

Sequence-specific assembly of FtsK hexamers establishes directional translocation on DNA

James E. Graham, David J. Sherratt, Mark D. Szczelkun and Stephen C. Kowalczykowski

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.67 MB

english, 2010

32

Structural insights into DNA sequence recognition by Type ISP restriction-modification enzymes

Kulkarni, Manasi, Nirwan, Neha, van Aelst, Kara, Szczelkun, Mark D., Saikrishnan, Kayarat

Journal:

Nucleic Acids Research

Year:

2016

Language:

english

File:

PDF, 4.34 MB

english, 2016

33

Re-evaluating the kinetics of ATP hydrolysis during initiation of DNA sliding by Type III restriction enzymes

Tóth, Júlia, Bollins, Jack, Szczelkun, Mark D.

Journal:

Nucleic Acids Research

Year:

2015

Language:

english

File:

PDF, 4.25 MB

english, 2015

34

Mapping DNA cleavage by the Type ISP restriction-modification enzymes following long-range communication between DNA sites in different orientations

van Aelst, Kara, Saikrishnan, Kayarat, Szczelkun, Mark D.

Journal:

Nucleic Acids Research

Year:

2015

Language:

english

File:

PDF, 7.93 MB

english, 2015

35

Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity

Tan, Benedict G., Wellesley, Frederick C., Savery, Nigel J., Szczelkun, Mark D.

Journal:

Nucleic Acids Research

Year:

2016

Language:

english

File:

PDF, 9.22 MB

english, 2016

36

CgII cleaves DNA using a mechanism distinct from other ATP-dependent restriction endonucleases

Toliusis, Paulius, Zaremba, Mindaugas, Silanskas, Arunas, Szczelkun, Mark D., Siksnys, Virginijus

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 3.43 MB

english, 2017

37

Hexameric assembly of the AAA+ protein McrB is necessary for GTPase activity

Nirwan, Neha, Singh, Pratima, Mishra, Gyana Gourab, Johnson, Christopher M, Szczelkun, Mark D, Inoue, Katsuaki, Vinothkumar, Kutti R, Saikrishnan, Kayarat

Journal:

Nucleic Acids Research

Year:

2018

Language:

english

File:

PDF, 2.74 MB

english, 2018

38

The Effect of DNA Topology on Observed Rates of R-Loop Formation and DNA Strand Cleavage by CRISPR Cas12a

van Aelst, Kara, Martínez-Santiago, Carlos, Cross, Stephen, Szczelkun, Mark

Journal:

Year:

2019

File:

PDF, 2.01 MB

2019

39

The Effect of DNA Topology on Observed Rates of R-Loop Formation and DNA Strand Cleavage by CRISPR Cas12a

van Aelst, Kara, Martínez-Santiago, Carlos, Cross, Stephen, Szczelkun, Mark

Journal:

Year:

2019

Language:

english

File:

PDF, 2.01 MB

english, 2019

40

5â² modifications to CRISPRâCas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage

Mullally, Grace, vanÂ Aelst, Kara, Naqvi, Mohsin M, Diffin, Fiona M, Karvelis, Tautvydas, Gasiunas, Giedrius, Siksnys, Virginijus, Szczelkun, Mark D

Journal:

Nucleic Acids Research

Year:

2020

File:

PDF, 6.16 MB

2020

41

Evolutionary Ecology and Interplay of Prokaryotic Innate and Adaptive Immune Systems

Dimitriu, Tatiana, Szczelkun, Mark D., Westra, Edze R.

Journal:

Current Biology

Year:

2020

File:

PDF, 1.36 MB

2020